Difference Between Acid and Shrooms (With Table)

Difference Between Acid and Shrooms (With Table)

Acid and shrooms are the two most used drugs for treating anxiety and PTSD. They get used for the same purpose but have different effects on the body. So, everyone should not take them without the consent of a doctor. 

It is important to know the scientific difference between the two drugs, acid (lysergic acid diethylamide) and shrooms (psilocybe cubensis) for protecting yourself and your family.

Acid vs Shroom

The main difference between the acid and the shroom is that the acid (lysergic acid diethylamide) contains lysergic acid that can be obtained from the fungus that grows on grain. It is purely synthetic. On the other hand, shrooms (psilocybe cubensis) are a mushroom that contains the natural compound that is psilocybin. 

The acid (lysergic acid diethylamide)  is a synthetic drug that contains lysergic acid, which can be found in fungi. This drug is commonly taken as a liquid or as a pill. It can also be taken directly in the mouth through paper soaked with the drug.

The shrooms (psilocybe cubensis) contain the nature-made psychedelic compound psilocybin. Psilocybin can be found in some parts of South America, the United States, and Mexico. This drug can be taken with other natural food, such as tea or juice. Some people also take this drug as dried and raw.

Comparison Table Between Acid and Shroom

OriginThis drug is obtained from psychedelic mushrooms, which contain a compound known as psilocybin. It is estimated that psychedelic mushrooms have more than two hundred species.This drug is obtained from psychedelic mushrooms which contain a compound known as psilocybin. It is estimated that psychedelic mushrooms have more than two hundred species.
SourceIt was invented in 1938. A Swiss Scientist, whose name was Albert Hoffman, first synthesized this drug.It is a man-made drug that has no odour, no taste, and is clear.
NatureIt is a man-made drug that has no odour, no taste and is clear.This drug is synthetic and is very bitter. That is the reason why people take it with some sweet drink.
Long-lasting effect The long-lasting effect of the acid is up to 20 hours.The long-lasting effect of shrooms is between four to six hours.
AntidepressantThis drug can potentially treat anxiety, PTSD, obsessive-compulsive disorder, depression, and addiction.This drug can treat anxiety, addiction, obsessive-compulsive disorder, and PTSD.
EffectIt affects the brain.It affects the brain.
BrainA brain, after taking this pill, works like it is dreaming.A brain, after taking this pill works like it is dreaming.

What is Acid?

Acid means LSD. This drug is used for treating anxiety and addiction. It was invented in 1938 by Swiss scientist Albert Hoffman, who himself took the drug and went for bike riding. It is a purely synthetic drug. 

LSD stimulates the synthetic nervous system of the body, which in turn increases the blood sugar level and the consumer’s body temperature. As these activities happen, the brain confuses them with the activity caused by serotonin and sends the signal to the brain’s synaptic cleft. When LSD reaches there, the serotonin receptor proteins start making bonds with the LSD. 

A team of scientists discovered that when serotonin, the drug (LSD), reaches the brain, the pattern of network communication, blood flow, and electrical activity changes. The drug consumer completely hallucinates when the barrier between the information-carrying regions and the visual cortex breaks down.

What is Shroom?

A mushroom is also an antidepressant drug used for treating anxiety and addiction. When someone takes the shrooms (psilocybin), the psilocybin enters the brain through the blood, where it starts forming bonds with the receptors of serotonin. 

The receptor gets activated by forming a bond with the psilocybin. This causes the visual cortex to become more vulnerable to the visual signal. The effect of psilocybin can not be seen until 15 minutes after taking the pill, which means the consumer will not experience any hallucination symptoms up to an hour after taking the drug. 

The liver takes the time between the consumption of the pill and the hallucination to break down the psilocybin into a compound known as psilocin. The ability of the brain to respond to negative things gets weekends during the process. The compound psilocybin, in the words of scientists, causes ‘ego dissolution. This means the psilocybin makes the frontoinsular cortex and the anterior cingulate cortex less responsive. 

Main Differences Between Acid and Shroom

  1. LSD (acid) is a synthetic drug. On the other hand, shroom (magic mushroom) is a natural drug.
  2. The effect of LSD starts immediately. On the other hand, the effect of shrooms does not start between 15 minutes to 1 hour after taking the drug.
  3. The effect of LSD lasts up to 20 hours. On the other hand, the effect of shrooms lasts up to six hours.
  4. The serotonin folds over the drug like a lid, which does not end the effect of it on consumers until the molecule pops off the receptor. On the other hand, there is no such thing as shrooms.
  5. The acid causes the brain to become hyperconnected. On the other hand, The shroom causes a slight loss of identity and heightened emotions.
  6. The acid contains a compound known as lysergic acid. On the other hand, the Shrooms release a compound known as psilocybin, which breaks down in psilocin inside the body.


The work of both the drugs (acid and shroom) is releasing serotonin. Both are used in treating a person suffering from anxiety, addiction, depression, and other mental diseases. 

The acid (LSD) and the shroom (Sweet mushroom) are the drugs that contain a  kind of chemical which can make bonds with the serotonin receptor part of the brain.


  1. https://www.sciencedirect.com/science/article/pii/B9780128156070000332
  2. https://n.neurology.org/content/66/12/1920.short
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