How Long After Metronidazole Can I Take Fluconazole (And Why)?

Exact Answer: After about 6 hours

Generally, doctors prescribe antibiotics as a treatment of most diseases. These antibiotics destroy the disease-causing bacteria present in the body.

But, sometimes they even destroy the useful bacteria present in the body. The destruction of useful bacteria leads to yeast infection.

Such infections occur on various parts of the body, in the private parts of the body.

Various bacteria and yeast are present in various locations of our body. One of them is Candida which grows uncontrolled in the female vagina to lead to infections.

The common symptoms of infection due to yeast are irritation around the vulva leading to itching and rashes. Such type of fungus infections need proper hygiene, care and atmosphere to get healed properly.

How Long After Metronidazole Can I Take Fluconazole


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How Long After Metronidazole Can I Take Fluconazole?

Minimum Time3 hrs.
Maximum Time6 hrs.

Vagina has a mixed proportion of bacteria and yeast to maintain its atmosphere. The chief bacteria present in the vagina is Lactobacillus, which gives the vagina its slight acidic tint.

However, it does not provide an atmosphere for the fungus to grow and create colonies. Consumption of antibiotics due to diseases like bronchitis or any kind of infection hampers the body’s balance of bacteria and fungus.

They erase away the traces of those bacteria which might harm the body.

However, these antibiotics also lead to mass destruction of the chief bacteria of the vagina thereby removing the acidity of the vagina. This sets the atmosphere for culturing of yeast.

In such cases, the doctor prescribes the patient to take some medicines like fluconazole along with other medicines to reduce the effect of those medicines.

These antifungal medicines play the role of good bacteria thereby protecting the vagina from excess growth of fungus.

Metronidazole is a medicine that is used to cure infections of the vagina caused due to any kind of microbes. It is even used to treat infection in other regions like the colon, pelvis and liver.

It is mainly prescribed in the form of a gel. It has been proven effective in many cases.


It is even used to cure ulcers and other problems of the digestive system. But, it fails to cure the infections or other problems caused due to virus.

Fluconazole is a type of azole antifungal which is used to treat infections and diseases caused due to virus. It is mainly prescribed to be taken orally in the form of tablets.

It is even used to cure infections of the urinary tract, pneumonia and other infections caused due to uncontrolled growth of Candida.

Why Should I Wait So Long To Take Fluconazole After Metronidazole?

However, both these drugs have some disadvantages besides all the advantages. Fluconazole can sometimes lead to improper functioning of the liver and heartbeat.

It may even lead to rashes and abnormality in the adrenal gland. However, if you experience any such symptoms, then you should stop taking the medicine and consult the doctor.

Generally, it is advised to talk to the doctor for all the information before taking the medicine.

Similarly, metronidazole may even lead to such problems as headache, pain in the abdomen, rashes, nausea, diarrhoea, dryness in the mouth, vomiting, loss of appetite leading to weight loss. Some serious side effects include sores in the mouth, pain during urination, meningitis and cancer in organs.


If the patient experiences any signs of discomfort, then it would be wise to consult the doctor at the earliest. These medicines may even lead to some serious diseases and hence should be taken only on being prescribed by the doctor.

However, metronidazole should not be used by pregnant women or breastfeeding mothers. It gets released through the milk of the mother and has the potential to affect the foetus and the newborn.

Fluconazole can even prove harmful for the foetus developing in the mother’s womb and hence should be avoided during pregnancy. However, during breastfeeding, there are fewer chances of the baby getting affected due to intake of the drug by the mother.

However, these medications should not be taken along with alcohol. Generally, we can see the writing on the label which states to avoid alcohol and other such narcotic substances during the intake of the medicine.

Intake of these medications along with alcohol and other such substances may lead to other complications thereby leading to death.


Both these medications should not be taken at a time. There must be a time gap of at least 6 hrs between the intake of Metronidazole and Fluconazole.

A time gap of a minimum of 72 hours should also be maintained if the person has consumed alcohol.

Although, no interactions have been noticed between Metronidazole and Fluconazole due to the difference in their mode of intake, yet, it is safest to maintain a minimum time gap as this would reduce the chances of complications.

However, one should take these medicines together if only the doctor has prescribed them. If the patient feels any discomfort or notices any anomaly, then he should go to the doctor immediately.



Last Updated : 23 February, 2024

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29 thoughts on “How Long After Metronidazole Can I Take Fluconazole (And Why)?”

  1. I never realized the precautions and timing of these medications are so critical. The detailed explanation offered here is significant for anyone taking these drugs.

    1. Avatar of Hunter Isabella
      Hunter Isabella

      The information regarding when to take Fluconazole after Metronidazole is valuable. It’s important to be well-informed about these things.

    2. Agreed, it’s essential to understand the implications of these medications, and this article provides that insight clearly.

  2. The detailed information on the potential risks and effects of these medications was enlightening. I’m grateful for the thorough explanation provided here.

    1. Absolutely, the article offers a comprehensive understanding of the potential effects of these medications.

    2. Yes, the detailed explanation was indeed enlightening. It’s vital to be aware of these things when taking medications.

  3. The side effects and potential risks of Metronidazole and Fluconazole were well explained. It’s essential knowledge for anyone taking these medications.

    1. I’m glad such detailed information was presented here. It’s crucial for everyone to be well-informed about these medications.

    2. The article presents an in-depth insight into the potential risks and side effects of these medications, which is important to be aware of.

  4. I never knew that antibiotics could lead to yeast infections. This article was very enlightening, and I’ll be more cautious next time I need to take antibiotics.

    1. I appreciate the warning about potential risks. It’s better to be informed about these things.

  5. The article’s detailed breakdown of the necessary precautions and potential side effects of these medications is essential knowledge for everyone. Well done.

    1. The detailed explanation of the side effects and risks of these medications serves as an important educational piece for all.

    2. Avatar of Jasmine Reynolds
      Jasmine Reynolds

      I completely agree. The information is well-presented and provides a great insight into these medications.

  6. This was really informative about medications and how they may affect our body. I appreciate the explanation about the importance of the waiting time between Metronidazole and Fluconazole.

    1. Thank you for explaining the side effects of these medications. It’s essential for everyone to understand their potential risks.

  7. The detailed explanation of the potential side effects of these medications is enlightening. It’s an essential read for anyone taking these drugs.

    1. I’m glad to have come across this informative piece. It’s crucial for everyone to be aware of the risks associated with these medications.

    2. Absolutely, this article provides vital information about the risks and side effects of these medications.

  8. This article’s breakdown on the effects of Metronidazole and Fluconazole is precisely what people need to know. It’s helpful and provides a great insight into these medications.

    1. I completely agree. The information here is invaluable and could help many people avoid adverse effects.

    2. I found this very enlightening and informative. Thank you for sharing such detailed information.

  9. The presentation of information regarding the effects and side effects of these medications is incredibly valuable. It’s essential knowledge for everyone.

    1. Agreed, the detailed explanation serves as a great educational piece for understanding the implications of these medications.

  10. The article offers a detailed explanation and warning of the potential side effects of these medications. It’s a valuable educational piece for everyone.

    1. I appreciate the thorough explanation provided here. It’s crucial knowledge that everyone should be aware of.

    2. Avatar of Walker Samantha
      Walker Samantha

      Absolutely, the detailed explanation is significant to understand the risks and effects of these medications.

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