How Long After Advil Can I Take Aleve (And Why)?

How Long After Advil Can I Take Aleve (And Why)?

Exact Answer: 10 Hours

People falling sick is as natural as getting cured. When a person is born into this world, that person has to experience a lot of things. Centuries back, a simple could become fatal but now due to advancements in medical science, people are getting cured of many serious diseases. It is the old people who need more medication than the young but exceptions exist in all fields.

People can have medicine without any prescription. There is a list of medications, which are kept by each person in their houses. They are mainly for fever, pain, cough and cold, etc. Advil and Aleve are two of the medicines among them. Even though they can be combined during a course, there should be at least a 10-hour gap between them.

How Long After Advil Can I Take Aleve

How Long After Advil Can I Take Aleve?

NSAIDDuration Of Action
Advil4-8 Hours
Aleve10-12 Hours

Taking Advil, a person should wait for at least 10 hours before having Aleve. This also applies if Aleve is taken first and then Advil. The 10 hours is not a strict schedule, but the gap between the dosage should be at least between 8 to 12 hours. As both of them are pain relievers, it is better to not take them at the same time even if the person is suffering from excruciating pain.

In the market, both Advil and Aleve are not known by their brand name. People recognize them as ibuprofen and naproxen, respectively. Both of them are the name of the drug. both of them are taken only when the person is having a fever or suffering from pain or inflammation. They are both termed NSAID or Non-Steroidal Anti-Inflammatory Drugs. Muscle pain, headaches, menstrual pain, etc., are other circumstances under which the medication is consumed.


Both of the drugs have a lot of similarities. Even if several medicines are made to cure the same disease, the chemical composition differs most of the time. But in the case of Advil and Aleve, both of their chemical structures are the same and are termed propionic acids. Due to being nonselective NSAIDs, both of them can be combined with COX1 and COX2 enzymes.

Not only similarities, but they also have a few differences. Being the same almost for every aspect, their dosage time and their term of duration of action differ from each other. Their intended use also differs, one is used more than than the other one.

Why Does It Take Long To Take Advil After Aleve?

Both Advil and Aleve are medicines that are given to people only when they are necessary. The 10-hour gap is not so long when speaking from a medical point of view. When first taken, the medicine needs time for action. Over time, when the effect wears off, another one can be taken. If both of them are taken at the same time it may have a side effect on the person consuming it.

The FDA or popularly known as the Food and Drug Administration, approved the use of both medicines for different purposes, even while both of them have the same chemical composition and are both NSAIDs. If a person is suffering from a rheumatoid disorder, premature infants, fever, etc., Advil is recommended. While if that person is suffering from, rheumatoid arthritis, pain, tendinitis, etc., Aleve will be his or her first choice.


The duration of action for Advil is much less than Aleve’s. The effects of Advil last for about 4 to 8 hours before another dose is taken. While the effects of Aleve last up to 10 to 12 hours. If necessary, Aleve is taken twice per day. These drugs also have side effects. The side effects include kidney, diseases, cardiovascular diseases, and digestive issues. Moreover, before taking any drugs, the doctor’s advice should be taken.


As mentioned above, there are a few side effects that may occur while the intake of the drugs. If a person has any kind of medical condition regarding kidney, heart, or digestive system, then that person should consult a doctor before taking the drug. Too many NSAIDs can result in many serious conditions. It may cause damage to the kidney and decrease its functionality, and bleeding from the stomach or the intestines.

There are also other problems like the ability to blood clot is delayed, thus increasing the blood loss. IF too much blood is lost, the person may lose his or her life. So every person taking these drugs should be extra careful.


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24 thoughts on “How Long After Advil Can I Take Aleve (And Why)?”

  1. This article is a very informative guide on the correct administration of pain medicines and the proper time separation between taking Advil and Aleve. I appreciate the emphasis on seeking professional medical advice before taking these medications, especially for patients with preexisting health conditions.

    1. I couldn’t agree more. It’s always best to consult with a doctor, especially when it comes to medications. The duration of action section was also particularly helpful in understanding how long the effects of each medication last.

    2. The detailed explanation about side-effects and potential health risks associated with excessive NSAID usage was crucial. This really puts the importance of following proper dosage and consulting a physician into perspective.

  2. This article serves as an invaluable guideline for understanding the biological and pharmacological aspects of Advil and Aleve. The emphasis on the importance of consulting medical advice and recognizing potential health risks is commendable.

    1. The detailed examination of the chemical composition and intended use of these drugs offers an enlightening perspective on the nuanced nature of pharmaceuticals. The emphasis on responsible medication use is particularly noteworthy.

    2. The article’s detailed exploration of the differing dosages and duration of action for Advil and Aleve provides a compelling insight into the complexities of pharmaceutical drugs and their impact on human physiology.

  3. The comprehensive examination of the pharmacological characteristics, intended use, and potential side effects of Advil and Aleve is commendable. It serves as a valuable resource for readers to understand the nuances of responsible medication usage.

    1. The article’s detailed exploration of the distinct characteristics of Advil and Aleve was particularly enlightening. The reminder to consult with a physician before using these medications is a crucial takeaway for readers.

    2. Avatar of Jonathan Walsh
      Jonathan Walsh

      The article’s balanced portrayal of the benefits and risks associated with NSAID usage offers an insightful perspective. It highlights the importance of consulting with a healthcare professional before taking these medications.

  4. It’s ironic how two drugs with similar chemical structures have differing recommended doses and duration of action. This article truly highlights the complexities of pharmaceutical drugs and their interaction with the human body.

    1. Absolutely! The comparison between Advil and Aleve, despite their similarities, showcases the intricate nature of medication and the importance of understanding how they impact the body differently.

  5. This article provides a comprehensive understanding of the pharmacological characteristics of Advil and Aleve. It serves as a valuable resource for individuals seeking clarity on the appropriate administration of these medications.

  6. The cautionary tone of the article, particularly regarding the potential side effects and health risks associated with NSAID usage, highlights the need for responsible pharmaceutical usage. It’s a valuable reminder for readers to exercise prudence with medications.

    1. I couldn’t agree more with the emphasis on the importance of responsible medication usage. The intricate details about the chemical composition and intended use of these drugs offer valuable insights into their pharmacological effects.

    2. The article’s detailed examination of the differences and similarities between Advil and Aleve, while illuminating, is also somewhat bewildering. It underscores the complexity of medication interaction with the human body.

  7. I find it perplexing that two distinct medications with similar chemical compositions have such contrasting effects in terms of duration of action and recommended dosing. The human body is truly fascinating in its response to different medicines and compounds.

  8. The comprehensive analysis of the distinctive characteristics and potential side effects of Advil and Aleve is enlightening. It underscores the need for cautious and informed pharmaceutical usage in managing pain and inflammation.

    1. This article provides a thought-provoking examination of the intricacies of Advil and Aleve. The focus on responsible medication administration and potential health risks is a compelling reminder for readers to exercise prudence.

    2. The article’s emphasis on understanding the chemical structures and mechanisms of action for Advil and Aleve is extremely informative. It provides vital insights into responsible medication usage.

  9. The scientific breakdown of how these drugs work is both fascinating and concerning. The human body’s response to different compounds and their potential side effects is a testament to the importance of seeking medical guidance.

    1. I was astounded by the detailed analysis of the possible side effects and complications that could arise from irresponsible medication use. It really underscores the significance of following expert medical advice.

    2. The difference in duration of action and suggested dosing for Advil and Aleve is indeed intriguing. It serves as a reminder of the multifaceted nature of pharmaceuticals and their impact on individual physiological responses.

  10. It’s quite concerning that the article only emphasizes the negative aspects of taking these medications and does not provide a balanced perspective. It’s important to consider the benefits of pain relief that these drugs provide when taken correctly.

    1. Avatar of Steve Phillips
      Steve Phillips

      While the potential risks were highlighted, I believe the intention was to caution readers about the importance of responsible medication usage. It’s a reminder that while these drugs can bring relief, they should be handled with care to avoid adverse effects.

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