How Long After Mifepristone Can I Take Misoprostol (And Why)?

Exact Answer: Six To Eight Hours

Mifepristone, scientifically termed RU-486, falls under medicines that help bring abortion when a woman is pregnant. It is taken in combination with misoprostol, and both these drugs together have been found very effective in getting abortion done. Currently, it is one of the best medicines to terminate pregnancy.

The protein binding of this drug is nearly ninety-eight percent. The molecular mass of the drug is 429.604 grams per mole, and its structure contains twenty-nine atoms of Carbon, one atom of nitrogen, along with two atoms of oxygen. The Hydrogen atom is responsible for filling the remaining valences.

How Long After Mifepristone Can I Take Misoprostol?

Mifepristone is a medicine that is taken orally by the mouth. The density of the drug is around 1.189 grams per milliliter. This medication’s melting and boiling point are very high and are close to 194 degrees centigrade and 629 degrees centigrade, respectively. The bioavailability of this drug is high as eighty-nine percent, and the Liver is responsible for metabolizing this drug in our body. The feces excrete Eighty-three percent of the drug, and nine percent of the drug is removed through the urine. The remaining percentage stays in the hair for a few months before they are excreted.

Mifeprex and Mifegyne are the other two names by which Mifepristone is traded in the market. This medicine was first prepared in France in the year 1987. Roussel-Ulcaf was a French pharmaceutical company that synthesized this drug in April. However, the medicine was approved for medical use seven years later, in 1987, after observing its efficacy. The United States approved the drug in 2000, and it is also on the list of essential medicines provided by the WHO. In Canada, the drug was approved in 2005 and rolled out in the market in 2007. The price and availability of this drug depend on the country itself.

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Time After Mifepristone To Take MisoprostolResults Obtained
Six to eight hoursGood efficacy and fewer side effects
Twenty-four hoursAverage efficacy but side effects are many

Misoprostol is taken after Mifepristone to perform abortion successfully. However, it has been observed that when misoprostol is taken six to eight hours after mifepristone, then the efficacy is excellent and side effects are few. In contrast, a time gap of twenty-four hours between both the drug has average efficacy and multiple side effects.

Why Does It Take That Long After Mifepristone To Take Misoprostol?

Misoprostol falls under the category of synthetic prostaglandin medication and helps treat medical conditions such as stomach ulcers. But it is also helpful in preventing pregnancy by abortion. The molecular mass of the drug is 382.451 grams per mole, and its structure contains twenty-two atoms of Carbon along with five atoms of oxygen. The Hydrogen atom is responsible for filling the remaining valences. The elimination half-life of the drug is twenty to forty minutes.

It takes that long after mifepristone to take misoprostol because as soon as mifepristone enters the body, it starts working. It creates suitable conditions for misoprostol to work and show its effects. If both the drugs are consumed simultaneously or immediately after one another, then mifepristone will take time to work, and misoprostol won’t effectively treat the condition. It is advised to take note from a medical expert on the time gap of both medicines.

Both mifepristone and misoprostol are very potent drugs and are sufficient for abortion. But they do have specific side effects. It is normal to feel dizziness and weakness after consuming the medicines. The patient might also feel hallucination and loss of vision in some cases. Severe symptoms might lead to diarrhea. Vomiting and constipation are two other side effects that are commonly observed.

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Conclusion

Finally, it can be concluded that mifepristone and misoprostol are two drugs to prevent pregnancy by performing an abortion. This drug combination is very effective and is also considered safe by medical experts. Mifepristone was first synthesized in a french laboratory in 1980.

On average, it is advised to take misoprostol six to eight hours after mifepristone for getting the best results. Significantly few side effects are observed in such cases. However, the patient can also take both drugs at a twenty-four-hour gap, but side effects can be severe in such cases. It is advised to consult a medical expert in case of any emergency.

References

  1. https://link.springer.com/article/10.2165/00003495-199345030-00007
  2. https://www.nejm.org/doi/full/10.1056/nejm200101043440107
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