How Long After Trigger Shot Is IUI Done (And Why)?

How Long After Trigger Shot Is IUI Done (And Why)?

Exact Answer:  After 24-36 hours

IUI termed Intrauterine insemination is considered as a very simple and safe therapy due to its capability of reducing serious complications. But this treatment includes few careful steps which are to be done before actual procedures. In most cases, IUI does not require any additional medications or supplements to get rid of pain and takes very few minutes to complete it.

To speed up the procedure or to get extra benefits out of it, trigger shot is used with therapies like IUI and IVF.  If the shot is required, your respective specialist will make you aware of it in addition to the IUI procedure and medications.

How Long After Trigger Shot Is IUI Done

How Long After The Trigger shot is IUI Done?

When a woman grows a follicle and proceeds with the procedures naturally without any drugs, she ovulates naturally and it is referred to as the natural IUI cycle. The trigger shot is an injectable medication also known as Ovidrel which is used along with other techniques or by itself.  It depends on factors size of the follicle and your endometrium. 

To cope up with the ovulation and without affecting the pregnancy, IUI is recommended and most specialists prefer to perform after 24 to 36 hours of trigger shot. During the time of ovulation, follicle size should be nearly 18 to 20mms. The measurements may vary depending on the physicians. You will be treated with a trigger shot when the follicle reaches 15 mm and when the uterine lining is 7 to 8mms thick. 

The time may also vary depending on the number of IUI done, if one IUI is done, a trigger shot is given, and IUI is performed after 36 hours, and if more than one IUI is done, IUI is performed after 24 or 48 hours after the trigger shot. To help with the implantation, few doctors advise taking supplements of progesterone may be by orally or vaginally. 

Though there are numerous advantages of trigger shots, you may experience various side effects like the stomach or pelvic pain, nausea, and bloating. The pregnancy test should be taken at least after 2 weeks of trigger shot to get worthy results as it takes nearly 12 to 14 days to remove from your system. Because, trigger shot contains HCG, which may tend to show positive results without being pregnant in case of testing before 14 days. 

Intrauterine insemination

In summary,

Number of IUIsFollicle sizeTime after shot
115mm36 hours
More than 115mm -20 mm24-48 hours

Why Does It Take That Long for IUI After Trigger Shot?

The trigger shot is preferred when IUI should be done even more precisely. Rather than waiting to release eggs naturally, this shot with the help of injected hormone stimulates to release of mature eggs to prepare for IUI. The IUI treatment is scheduled between 24 to 36 hours of the post-trigger shot.

This shot triggers the body to release eggs as it contains HCG to the tune of 5,000 or 10,000 IUs. In few cases, time doesn’t matter for IUI therapy after the shot, but the sperm should be available, reasonably close during and preceding ovulation. Since the time of ovulation is unknown, it can take a minimum of 12 hours to reach out to an egg and enter the fallopian tube. Generally, the follicle grows nearly up to 2mms each day but this relies on the individual.

trigger shot IUI

This is the reason when ultrasound is recommended when you get closer. The journey of fertilization to implantation could take nearly 5 to 9 days and in rare cases, it extends up to 12 days. Normally, the success rate of trigger shot alone is very less, but when combined with other procedures like IUI or IVF it proves to be beneficial.

Similarly, the rate of pregnancy with only IUI treatment would be 6% whereas when combined with trigger short, the success rate could be around 18 to 20 percent. According to the study, when the trigger shot was done concerning a woman’s natural LH surge, the pregnancy rate was above 25 percent.


You might feel little tenderness, discomfort, and pain at the injection site which will subside naturally. Before proceeding for a trigger shot along with IUI, list out its benefits and effects. It would be worth doing only during timed intercourse like IUI or IVF. But the success rate also depends on age, type of infertility, and few other conditions too.

Things like tracking the size of the follicle and uterus lining are mandatory to undergo a trigger shot. Even though when you prefer IVF with follicle size 15 to 20mms, the timing would be the same as for IUI.


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19 thoughts on “How Long After Trigger Shot Is IUI Done (And Why)?”

  1. The article provides a detailed breakdown of timelines and the reasons behind them, which would greatly benefit those about to undergo IUI treatment.

    1. Absolutely, understanding the timing and biological processes involved is crucial for those undertaking this procedure.

  2. While the article offers valuable knowledge, it’s crucial to remember that individual responses to these treatments can vary. This should always be discussed with a specialist before proceeding.

  3. The thorough explanation of the trigger shot and its timing in relation to IUI provides valuable insights into the entire process.

  4. The detailed facts and figures presented in the article contribute to a more informed understanding of IUI and the trigger shot treatment.

  5. The article provides an insightful and informative look into the complexities and details of IUI and trigger shot therapy, making it easier for people to weigh their options and make informed decisions.

    1. Avatar of Sabrina Mitchell
      Sabrina Mitchell

      Absolutely, the article serves as a comprehensive guide for those navigating the possibility of this treatment.

  6. The detailed explanation, complete with success rates, adds to the overall educational aspect of the article. It’s certainly insightful for anyone interested in this treatment.

    1. Agreed, the inclusion of success rates provides realistic expectations and grounds those considering this course of action.

  7. The article provides a clear and concise explanation of IUI and the trigger shot process. This is helpful for those considering the procedure.

  8. The benefits and side effects of the trigger shot are explained thoroughly, giving a well-rounded view of what to expect from this treatment.

    1. I appreciate the balanced perspective provided. It certainly helps in making informed decisions regarding fertility treatments.

    2. The article does cover a wide range of aspects. It helps individuals assess the decision to undergo such treatment with more clarity.

  9. This treatment seems quite promising and less invasive. It could be a viable option for many couples seeking to conceive.

  10. The article seems well-researched and provides essential information for those looking into IUI and the trigger shot. However, it might still be beneficial to seek direct medical advice when considering such procedures.

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