How Long After Zofran Can You Eat (And Why)?

Exact Answer: 30 minutes to 1 hour

Zofran is an antiemetic and the brand name for the drug Ondansetron, which is a form of medication used to prevent nausea and vomiting mostly caused by the treatment for cancer or surgery. It is also used in the treatment of gastroenteritis.

It can be administered orally, intravenously, or injected into the muscle. It may side effects that include headache, drowsiness, tiredness, dizziness, and constipation. People at high risk of heart issues should be aware that Ondansetron can cause QT prolongation, affecting the heart rhythm. That is why before taking this medication, the doctor or medical practitioner should be aware of all the medication the patient is undergoing.

How Long After Zofran Can You Eat

How Long After Zofran Can You Eat?

Zofran should be taken exactly as prescribed by the doctor. This medication can be administered with or without food. If one is consuming the tablet form of Zostran for nausea that occurs with meals, the tablet should be taken at least 30 minutes to 1 hour before meals. The Zofran tablet should be taken with a full glass of water.

If one is consuming the orally disintegrating tablet, Zofran ODT, that can be taken even 15 minutes before meals. One should be careful not to touch the tablet with wet hands. After opening the tablet and placing it in the mouth, let it dissolve without chewing and then swallow it.
When consuming the oral soluble film, the liquid can be taken up to 15 minutes before the meal. It is necessary to measure the liquid medicine with the dosing syringe, or with a dose-measuring cup/spoon.

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It is to be noted that if you are taking ondansetron for constant, all-day nausea then it should be administered regularly all through the day as instructed by the doctor, with or without food.

To prevent nausea and vomiting from chemotherapy, it is advisable to take Ondansetron by mouth at least 30 minutes before the treatment or procedure. In the case of nausea caused due to radiation treatment, this drug should be taken 1 to 2 hours before the treatment. To prevent nausea after surgery, one must take it at least an hour before surgery.

Zofran FormTime after which you can eat
Zofran tablet30 minutes to 1 hour
Zofran ODT15minutes
Zofran Liquid15 minutes

Why Can you Eat That Long After Zofran?

Ondansetron works in the stomach in a way that restricts the signals to the brain that cause vomiting and nausea. When consumed, the tablets will begin working within half an hour to 2 hours. It takes a little longer than other forms of the same drug to enter into the bloodstream and deliver its effectiveness, and is therefore advised to be taken at least 30 minutes to an hour before any food consumption.

The orally disintegrating tablets, Zofran ODT, are known to be quickly absorbed into the blood and therefore work faster than the tablet. That is why a person needs to wait for a reduced time of 15 minutes (as compared to 30 minutes to 1 hour of the standard tablet) before consuming any food. The oral soluble film works in almost the same manner, thereby enabling faster uptake of the medication into the bloodstream, making it equally efficient.


It is a well-known fact that this type of medication works the fastest on empty stomach- which is ideally an hour before food or even 2 hours after food. When consuming any form of Ondansetron, the minimum time taken to allow the medication to have its effect should be the period before which one should not eat any food. This will allow the medication to work effectively and efficiently.

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Zofran is an antiemetic, meaning that it is used to avoid nausea and vomiting. It is important to note that although it may be used while treating cancer- chemotherapy and radiation therapy, during surgery, and for treating gastroenteritis, it is not effective against motion sickness.
Zofran is a drug that has several side effects including headache, feeling tired, drowsiness, constipation, etc, and must therefore be taken under the proper guidance of a doctor or medical practitioner. Proper dosage is essential for its effective working. Consumption of any form of food must be done in accordance with the time each type of medication requires to be assimilated by the body.



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Hi! I'm Nidhi.

Here at the EHL, it's all about delicious, easy recipes for casual entertaining. So come and join me at the beach, relax and enjoy the food.


  1. Very informative post. I had been taking Zofran but I never knew it should be taken at least 30 minutes to 1 hour before meals.

    1. It’s fascinating to consider all the different factors that can affect the effectiveness of the drug.

  2. Zofran dissolvable tablets are really interesting. It’s great to have this option fo when I can’t swallow a pill

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