How Long After PGS Is Transfer (And Why)?

Exact Answer: Five To Ten Days

PGS stands for preimplantation genetic screening. The term is generally used to define a set of techniques that help test whether the embryos obtained by various fertilization methods contain abnormal chromosomes. PGS is also referred to as aneuploidy screening. The process is widely popular in different parts of the world.

In other words, the process is usually carried out to find whether an embryo is aneuploid or not. The process is sometimes also termed generic preimplantation profiling because the method is sometimes used on embryos or oocytes before implantations for reasons other than screening. The process is also used for fertilization.

How Long After PGS Is Transfer?

The process was first successful in the year 1968. Richard Gardner and Robert Edwards successfully identified the sex of a rabbit blastocyst. However, it took some time for the process to be successful for humans. Winston, Kontogianni, and Handyside were the first ones to report positive results in humans. They completed the test successfully in October 1989. The first birth of the trial took place in the year 1990. In the first test, female embryos were transferred to five couples at the risk of X-linked disease. One singleton pregnancy and two twins were obtained as a result of the test.

Initially, PCR was used as a method for determining the sex of patients carrying different X-linked diseases. The process is also used for the screening of a specific genetic disorder. The main advantage of the process is that it helps avoid selective abortion and ensures that the embryo fertilized will be free of any disease under consideration. The process works as an adjunct to various reproductive technologies. In vitro fertilization is required to obtain seeds or oocytes for evaluation.

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Type Of TransferTime After PGS For Transfer
Single embryo transferFive to six days
Multiple embryo transferEight to ten days

It takes time after the procedure to transfer the embryo into a woman’s uterus. If there is a single embryo transfer, then it takes five to six days after the PGS for the transfer. In case of multiple embryo transfer, it is advised to wait for eight to ten days to get all the embryos transferred.

Why Does It Take That Long After PGS For Transfer?

During the PGS procedure, a single cell or multiple cells are removed from the embryo. After that, the DNA of all the cells is tested to confirm whether they have any chromosomal abnormalities or not. Once it is confirmed that an embryo has no chromosomal abnormalities, it is placed in the womb. The process includes taking a biopsy. It is done to remove all the cells with chromosomal abnormalities. However, this can sometimes damage the embryo and prevent it from developing after being transferred into the womb.

It takes that long after PGS for transfer because the screening ensures no chromosomes left are abnormal. It takes time to test all the chromosomes and removing a chromosome if it has any abnormalities. The process is that long because medical experts want to ensure that the embryo will develop ultimately after getting placed in the woman’s womb. The results are verified twice for more precision and accuracy.

The woman who uses this procedure for getting an embryo placed in her womb must ensure that an authorized medical expert is performing the procedure. PGS is an empathetic process and must be done by a doctor who is highly experienced. The woman must keep patience until the embryo is transferred. Any negligence in the process can prove harmful for the embryo. It is also confirmed that all the genetics of the embryo matches the required condition.

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Conclusion

Finally, it can be concluded that PGS is a process that helps in transferring an embryo to a woman’s womb after various fertilization techniques. The process was first reported successful in 1968 in animals and the year 1989 in humans. The method determines the aneuploidy or not.

On average, it takes five to six days for transfer after the PGS if it is a single embryo. In the case of multiple embryos, the time for transfer usually lies between eight to ten days. The embryo must be free of any chromosomal abnormalities to develop entirely after getting placed in the womb.

References

  1. https://www.nejm.org/doi/full/10.1056/nejmoa067744
  2. https://academic.oup.com/humrep/article-abstract/29/9/1846/2427550
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