How Long After Prednisone Can I Take Aspirin (And Why)?

Exact Answer: At Least Six Hours

Prednisone falls under the category of glucocorticoid medicines that are most helpful in suppressing the immune system. It is also responsible for decreasing inflammations in various conditions such as Chronic obstructive pulmonary disease, asthma, and rheumatologic diseases. The medicine is also helpful in treating high blood calcium caused due to adrenal insufficiency, cancer, and other steroids.

Prednisone is a type of prodrug and is converted into prednisolone. The liver is responsible for the conversion of prednisone inside our body. Prednisone is only activated after it gets converted by the liver. Prednisone is a kind of generic medication.

How Long After Prednisone Can I Take Aspirin

How Long After Prednisone Can I Take Aspirin?

Prednisone was first produced in 1954, and it was approved for medical use by the United States government in 1955. Prednisone helps treat many conditions, including inflammation, adrenal problems, severe allergies, asthma, arthritis, bone or blood marrow problems, eye or vision problems, endocrine problems, lupus, stomach or bowel problems, kidney problems, skin conditions, flare-ups, and ulcerative colitis. The medicine helps in lowering the activities performed by our immune system. It is also instrumental in providing relief to various affected areas of our body. The drug can only be purchased with a genuine doctor’s prescription.

Prednisone has also been used to treat various cluster headaches and migraine headaches and in cases of severe aphthous ulcer. It is also widely prescribed as an antitumor drug. It is also helpful in treating multiple myeloma, Hodgkin’s lymphoma, non-Hodgkin lymphomas, acute lymphoblastic leukemia, and various other hormone-sensitive tumors. Prednisone is also used for the treatment of heart failure.

Age Group Of The PatientTime After Prednisone To Take Aspirin
MinorsTen to twelve hours
AdultsSix to eight hours

It is advised not to take aspirin just after consuming prednisone as it will lead to severe complications. Health experts believe that a minor should avoid using aspirin for at least ten hours after taking prednisone as their immune system is under the developing phase, and there could be a lot of side effects. In adults, aspirin can be used after six to eight hours of taking prednisone as the immune system of an adult is fully developed and can convert the drug faster than a minor.

Why Does It Take That Long After Prednisone To Take Aspirin?

Aspirin is a form of acetylsalicylic acid and, when combined with prednisone, can cause many problems for the patient. If a body contains both prednisone and aspirin simultaneously, it will increase the risk of various side effects, especially in the gastrointestinal tract. It increases the chances of ulceration, bleeding, and rarely perforation. Apart from this, aspirin affects the working of prednisone, and the medicine might not be able to perform its work correctly. If a patient is taking both the drugs, then it is very crucial to consult a doctor and make a schedule of taking both the medicines.

Prednisone itself has various side effects. Some of the most common side effects of the drug include bone loss, cataracts, muscle weakness, easy bruising, and thrush. Some other side effects include swelling, obesity, risk of infection, high blood sugar, and psychosis. However, doctors allow the use of the drug in pregnancy, but it is advised to take the medication in low quantities when a woman is breastfeeding.

However, if a person is taking prednisone for a long time, it won’t be an excellent option to stop the drug use immediately as it will have severe effects on the body. Medical experts recommend a gradual decrease in the intake of the drug before finally stopping its use. Prednisone is also known for triggering changes in our gene expression.


Finally, it can be concluded that prednisone is a drug used to treat various diseases. Inside our body, the liver converts the medicine into prednisolone. However, only an authorized medical expert can prescribe the medication for oral use.

On average, an adult must wait at least six hours after taking prednisone to use aspirin. Minors should not use aspirin for up to ten hours after taking the drug. Taking both the medicines simultaneously can prove to be harmful to our immune system, and it is very vital to make a routine with the doctor before proceeding with the use of both the drugs.


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