How Long After Tylenol Can I Give Benadryl (And Why)?

Exact Answer: No interaction found (consult your doctor)

Medicine is the science of treating, handling, preventing, and stopping sickness. Tylenol is the trade name of Paracetamol which is also known as acetaminophen. It is a medication that is used for the treatment of fever and mild to moderate pain. 

It may relieve pain in acute mild migraines. It is also effective for post-surgical pain. Benadryl is the trade name of Diphenhydramine. It is an antihistamine that is mainly used to treat allergies. This medication can also be used to cure symptoms of common cold, cough, and nausea. The maximal effect of  Benadryl is around two hours and it can last up to seven hours.

How Long After Tylenol Can I Give Benadryl


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How Long After Tylenol Can I Give Benadryl?

Age groupTylenol Doses
Adults (weight 50kg)less than 4000mg
Children (age 12 years)Less than 3250mg

There are no interactions found between Tylenol and Benadryl so they can be taken together or else can be taken as directed by the doctor or pharmacist. Tylenol can be used as directed on the label or by the physician. Tylenol should not be used with the medicine that contains acetaminophen. It could cause a fatal overdose. 

Dosages for Tylenol are different for various age groups.  People who weigh at least 50kg must not consume 1000mg at a time. It is advised not to take 4000mg in 24 hours. Children less than 12 years of age must not take more than 5 dosages of the above-mentioned medication in 24 hours. 

Tylenol is manufactured by McNeil Consumer Products Company. It is a subsidiary of Johnson and Johnson. Mr. McNeil, who died at the age of 94, created Tylenol in 1955.Benadryl is advised to take as per label or as prescribed by the physician. Adults must not take Benadryl more than 300mg in a day. 


Children are advised to take less than 150 mg in a day. Benadryl spray must not be applied more than 5 times in a day. This condition applies to both adults and children. Benadryl dosages depend on several factors like the type of condition, age, and the form of medication you are taking. The body’s response to Benadryl may decrease with time.

Benadryl was invented by an American chemist and professor George Rieveschl. It came to commercial use in the year 1946. It was approved by the FDA(Food and Drug Administration).

Why Can I Give Benadryl So Long After Tylenol?

Side effects of Tylenol and Benadryl can be treated by each other and both Tylenol and Benadryl don’t have interactions or reactions between them. Hence they can be given together to get the best results. Tylenol which contains acetaminophen is an antipyretic and analgesic which is used to treat fever and pain. It includes common side effects such as dark urine, stomach pain, rashes, itching, dizziness, and swelling.

Tylenol can be used during any stage of pregnancy or even during breastfeeding because acetaminophen is released in a very little amount through breast milk and hence cannot affect the infant or newborn.

Major side effects include severe liver damage. Our liver processes with Tylenol and releases some substances. Consuming more of this medication results in an increase of that substance which results in severe liver damage. Some major symptoms of liver damage include jaundice, vomiting, nausea, pale skin, unusual bleeding, fatigue, sweating more than usual and abdominal pain. Side effects can also be seen after completing the dosages.


Benadryl’s generic name is Diphenhydramine which is an antihistamine used to cure dizziness, nausea, vomiting, runny nose, and sneezing. Just like Tylenol it also includes common side effects such as constipation, dry mouth/throat/nose, fatigue, tiredness, sleeplessness, drowsiness etc.

Benadryl is released in mother’s milk which can affect the infant or newborn. Hence Benadryl is not advised during pregnancy or for nursing mothers. Major side effects involve fast and irregular beating of the heart, mood swings, or restlessness. One should contact the doctor immediately if he/she notices any symptoms. 


It can be concluded that medicines have many side effects and they should be used when prescribed by a professional. Tylenol contains acetaminophen which is used to cure mild to moderate fever and pain, but except for its efficiency and popularity, it is also the main reason for acute liver failure.

Benadryl consists of Diphenhydramine which reverses the action of histamine on capillaries which results in reducing allergic symptoms. Besides these results, it also leads to an increase in blood pressure levels, irregular heartbeats, mood swings, dizziness, and much more. Every coin has two sides, likewise medicines are required to be used carefully to get the best results. One should try ancient Indian medications like Ginger, Honey, and Tulsi to get rid of the common cold, nausea etc. If it is not cured, then only one should go for medicines.



Last Updated : 23 February, 2024

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