How Long After Xanax Can You Take Benadryl (And Why)?

Exact Answer: After about 2-3 hours

Xanax and Benadryl are two medicines with different chemical compositions. Xanax is also known as alprazolam, this is used in the treatment of anxiety and panic disorders.

Similarly, Benadryl is also known as diphenhydramine which is an antihistamine, this is used in the treatment of hay fever, allergy, cold, etc. 

We can not take both the medicines that are Xanax and Benadryl at a time. So an interval is kept between taking the doses of both the medicine as prescribed by doctors.

Both have their functions for the treatment of different diseases and to show their effects. Alprazolam is a medicine that is mainly used to cure disorders related to anxiety and panic.

How Long After Xanax Can You Take Benadryl

How Long After Xanax Can You Take Benadryl?

For adults3 hrs
For children5 hrs

Alprazolam is classified into a group of medications known as benzodiazepines. These are the groups of medicines that act on and show effects in the CNS of the body.

This way, they help us in having a calming effect. This also produces a soothing effect on the mind. These medications show effects by increasing the secretion of GABA.

Diphenhydramine is another medication that is used for the same purpose, i.e. to pacify the disturbed mind. This works by causing the blockage of a specific natural substance produced by the body during allergic reactions. i.e. histamine It even has drying effects and other symptoms.


These medications show results by causing the blockage of other natural substances made by your body. These are not cold products children below 6 years of age should not consume.

Hence, this product should not be prescribed to cure symptoms of cold in children below the age of 5-6 years. However, when prescribed by a doctor, it’s completely safe.

One should carefully read the prescription given by the doctors and should collect the information about the medicines i.e. alprazolam and Benadryl. These medicines are taken by mouth according to the dosage prescribed by the doctor.

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The dosage varies for all age groups. It is prescribed keeping in mind the health condition, underlying health issues, age, and sex of a person. The dosage may be increased in small amounts in case the medication takes time to show results.

In case of taking both doses, one should be very careful of maintaining the minimum time interval between them which is 2 – 3 hours. Initially, after consuming Xanax we have to wait for 2 – 3 hours for consuming Benadryl otherwise it may show some side effects or risky health issues.

Hence, the number of doses and the time interval is the most important thing to look after while taking both the medication in one day. Or else, we should ask someone to remind us about the important details in time.

Why Can You Take Benadryl So Long After Xanax? 

These medications are helpful for our bodies. Besides their benefits, we must be aware that they shouldn’t be taken together.

Xanax Tablet

Taking Xanax and Benadryl together can have adverse side effects like dizziness, lack of concentration and coordination, fatigue, feeling of drowsiness, etc. Combining Benadryl and Xanax can be especially dangerous for elderly individuals. 

Drugs interact within themselves. Similarly, the intake of these two medications together may lead to intensified effects of both.

Sometimes, their combined side effects may even lead to a horrible chain of physical reactions. The main reason behind why one should not take both chemically strong medicine together is because both of them are quite addictive.

Once a person gets accustomed to frequently taking both together, he/she may require residential addiction treatment to quit. Some adverse side effects of Xanax include a feeling of dizziness, blurred speech, loss of coordination, memory failure cases, trouble faced during breathing, hallucinations, etc.

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These symptoms are observed when Xanax is taken in extreme doses. People gradually develop a tolerance toward strong medication.

This forces them to take a higher dosage more than required to experience the same effects. Some most possible side effects of Benadryl include dryness of mouth, feeling of dizziness, constipation, severe pain in the stomach, blurry vision, throat infections, confusion in the mind, and irregular heartbeat.

Xanax Contents

Benadryl is considered addictive only due to the presence of its key ingredient, diphenhydramine. As it is an OTC medicine, people mainly access it in the form of tablets.

Sometimes, it is also available in capsules and liquid form. People who develop an addiction to it may need professional help to quit.


As both these medications are highly addictive medicines, taking them at a time may lead to side effects such as high levels of dizziness. Sometimes, severe side effects may also occur in the body which may further lead to cardiac arrest and high blood pressure or numbness or weakness in the body. 

As we know, excess of everything may lead to a highly destructive environment. Exactly, in the same way, excess drugs used may lead to serious risk towards one’s life.

These types of medicines are taken when our body doesn’t improve in the less power-dosed medicine and stays in the risky condition.

Those medicines are not provided without a prescription in the medical stores because they can be dangerous or fatigue.



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Hi! I'm Nidhi.

Here at the EHL, it's all about delicious, easy recipes for casual entertaining. So come and join me at the beach, relax and enjoy the food.


  1. This post is a standout in terms of providing crucial information about the risks of Xanax and Benadryl interactions.

    1. Thank you for breaking down the potential side effects of taking these medications together so clearly.

  2. Well-written and well-researched, this is a helpful guide for understanding the potential risks of mixing Xanax and Benadryl.

    1. This post could not have been more accurate, it’s crucial to understand the interactions between different drugs.

  3. This article serves as a reminder of the importance of understanding drug interactions and their potential consequences.

    1. Thank you for addressing the significant risks associated with combining Xanax and Benadryl in such detail.

  4. I’m glad an article like this exists, it’s important to spread awareness about the dangers of combining Xanax and Benadryl.

    1. Absolutely, everyone should educate themselves on the potential risks of taking these medications together.

  5. A well-researched and comprehensive article that offers essential insights into the risks of taking Xanax and Benadryl together.

    1. This article is an excellent resource for understanding medication safety and potential interactions.

  6. Informative and well-presented, this post has addressed an important issue with clarity and detail.

    1. Couldn’t agree more, it’s vital to understand the potential dangers associated with medication interactions.

    2. This is an invaluable resource, many people will benefit from understanding the risks outlined in this article.

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