How Long Does it Take for Tylenol to Kick in - (And Why)?

How Long Does it Take for Tylenol to Kick in – (And Why)?

Exact Answer: 45 minutes

Tylenol is used as a moderate pain reliever along with fever and headache. This is one of the most common drugs in the United States.

The active ingredient of these drugs is known as acetaminophen, which is the same compound used in Paracetamol. When using Tylenol as a painkiller, it is advisable to use four to six timers per day.

However, the amount should not exceed 3,000mg per day for adults. When it comes to children below the age of 2 years, Tylenol should not be used without a doctor’s prescription.

In this article, we shall discuss how long does it take for Tylenol to kick in and why.

How Long Does it Take for Tylenol to Kick in

How long does it take Tylenol to kick in?

Induction ProcessTime Taken Before Effects Kick In
Ora45 minutes
Disintegrating tablets20 minutes
Rectal suppositoriesTwo hours

When taking Tylenol as a painkiller or lowering fever, the effect will kick in after 45 minutes for tablet, oral or liquid Tylenol. When it comes to disintegrating tablets, the results are said to kick in within 20 minutes.

For rectal suppositories, the effect will take long before it kicks in approximately two hours. Tylenol lasts for four hours as it reduces fever and relieving pain.

Taking it more will help ease both fever and pain. If the pain or fever persists within one to two hours after using Tylenol, it is advisable to contact your pharmacist for further more assistance.

Why does it take long for Tylenol effects to kick in?

One of the critical factors that affect the time taken for the Tylenol effect to kick in is metabolism. You should note that metabolism tends to differ from an individual to the other.

Furthermore, the method in which the drug is induced into the body will affect the time taken for its effect to kick in. Using liquid or tablet Tylenol, the result will kick in within 45 minutes, unlike rectal suppositories, where it will take approximately two hours before the effects kick in.

How Safe is Tylenol?

According to the current research using a maximum of 3,000 mg per day is considered safe. Furthermore, using 4,000mg under physician care is said to be safe, as well.

Nevertheless, consuming more than 4,000 mg of Tylenol per day is said to be hazardous since it can lead to liver damage. If you have any liver infection, Tylenol is considered not safe for use.

If you have a history of alcohol abuse, you are advised not to use Tylenol. Furthermore, you should not use the drug while drinking alcohol.

Furthermore, if you have a history of liver disease, including hepatitis as well as phenylketonuria and severe kidney disease using Tylenol is highly prohibited. When taking blood thinners such warfarin, it advisable to consult your doctor before using Tylenol.


When you develop a rash, swelling, or difficulty in breathing as a result of using Tylenol, it is highly recommended to contact your doctor. When developing nausea when using the drug, you might consider using milk to calm the effect down.


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Hi! I'm Nidhi.

Here at the EHL, it's all about delicious, easy recipes for casual entertaining. So come and join me at the beach, relax and enjoy the food.


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