How Long Do Iron Infusion Side Effects Last (And Why)

Exact Answer: 1 – 2 days

When a therapy produces an issue because it treats more than the target tissue, it is called a side effect. The consequences might range from modest to severe and perhaps fatal.



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Although a favorable side effect is possible, an adverse consequence is undesirable. The therapy might be a pharmaceutical, a surgical procedure, or another type of intervention, such as complementary and alternative therapies, which can cause adverse effects.

When iron is infused into a person’s body, it is done so using an intravenous line. Anemia or a low red blood cell count can be cured or improved by increasing the quantity of iron in a person’s blood.

A needle is used to inject iv iron into a patient’s vein. The process takes place at a physician’s surgery and might take hours, based on the treatment that the doctor has ordered.

Patients with intestinal bleeding, irritable bowel syndrome, renal dialysis, iron deficiency anemia, heavy blood loss operation, and celiac disease need iron supplements.


How Long Do Iron Infusion Side Effects Last?

Methods of infusionLasts for
Iron injections1 – 2 days
Iron infusions 1 – 2 days

After receiving an iron infusion, a person may have moderate side effects for 1-2 days.

Iron can be given to patients in the form of an injection or an infusion. Intramuscular iron injections are commonly delivered into the buttocks. While iron injections are speedier than iron infusions, they are not without risks. Pain and bleeding into the muscle are examples of these.

Bloating or swelling of the face, arms, hands, legs, or feet; headache, uneasiness, unexplained weight gain or loss; slow or rapid pulse; and difficult or strained breathing are all adverse effects of iron infusion. Low blood pressure and fainting are two less common adverse effects.

There may be some side effects that do not require medical treatment. When your body responds to medications, these side effects may gradually disappear throughout treatment. As a result, your health care provider will be able to advise you on how to avoid or mitigate some of these adverse effects.

Why Do Iron Infusion Side Effects Last That Long?

Iron infusion has very few negative effects. The severity of side effects varies for each patient, based on their overall health, illness stage, age, weight, and gender. There are three levels of severity: mild, moderate, and severe. Mild side effects might last up to two days, but severe side effects can last months or even years.

The leaking of iron into the tissues around the needle (drip) site might cause skin staining (brown discoloration). Although this fact is unusual, the stain might be long-lasting or permanent. Any pain, burning, redness, or swelling at the needle (drip) site should be reported to the doctor or nurse right soon.

Iron poisoning is an uncommon but significant side effect of iron infusions. Iron poisoning symptoms might appear suddenly, resulting in anaphylactic shock. They might also appear gradually over time. With time, iron toxicity develops, resulting in an excess of iron in the body’s tissues. This is usually dangerous.  

To avoid this problem, the test dose and the slow infusion rate are both used. If you have a history of several medication allergies, the test dose is especially crucial. The test dose will be used by your doctor to keep an eye on you for any responses. Shock, collapse, low blood pressure, and loss of consciousness are examples of these responses.

If any adverse effects occur after an iron infusion or if they interfere with your normal activities, get medical assistance from your doctor or infusion facility. If you experience any negative effects, you can contact the FDA at 1-800-FDA-1088.


To those with low hemoglobin levels, iron infusions are not the best option. Iron infusions are one option for boosting iron levels in a person with iron insufficiency who cannot take or does not react to iron supplements. Although iron loss is not without its dangers, better formulations can help reduce adverse reactions.


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