How Long Does It Take For Cymbalta To Work For Neuropathy (And Why)?

Exact Answer: Six To Eight Weeks

Neuropathy is a serious illness that can happen to patients which can also become the primary reason for permanent nerve damage. Although there are medications available for neuropathy, it still takes time to work on the body and bring results.

When it comes to neuropathy, proper medication is of extreme importance. One such medication is Cymbalta. Cymbalta is also known as Duloxetine. Cymbalta is an antidepressant, or precisely, Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor antidepressant.

Cymbalta or Duloxetine is widely used in cases of neuropathy.

How Long Does It Take For Cymbalta To Work For Neuropathy

How Long Does It Take For Cymbalta To Work For Neuropathy?

When one or more nerves in the body face damage, the condition is called neuropathy. Prominently neuropathy can be understood when there is a tingling sensation or numbness in the body part that is affected. It is common for neuropathy to affect hands or feet when it starts. However, it can happen in other body parts too.

Due to the composition of Cymbalta, it is an ideal medication for neuropathy. Since Cymbalta is a serotonin and norepinephrine reuptake inhibitor, it is often used in the treatment of both diabetic and peripheral neuropathy.

Seratonin and norepinephrine are neurotransmitters in the central nervous system. The reuptake of the neurotransmitters can cause neuropathy. Cymbalta prevents the reuptake and helps in recovery from neuropathy. On average, it can take about six to eight weeks for visible results after starting the consumption of Cymbalta.

The timeframe that it will take for Cymbalta to work for a case of neuropathy depends on many factors like the age of the person or the severity of the neuropathy in the patient. Cymbalta is known to work successfully once the signs and symptoms start to reduce.

Dosage of CymbaltaThe time it will take for Cymbalta to work
Low dosageEight to twelve weeks
Medium dosageSix to eight weeks

Why Does It Take So Long For Cymbalta To Work For Neuropathy?

There are many factors behind the time it can take for Cymbalta to work for neuropathy. One of the primary factors is the severity of the case for neuropathy. In cases where the is severe, it can take much longer for Cymbalta to work compared to the mild case of neuropathy.

Other than the case, the period for which the patient has been suffering from neuropathy also influences the time it takes for Cymbalta to work. If a patient has been suffering from neuropathy for a long time, it will take more time for Cymbalta to work for neuropathy.

On the other hand, when the period for which the patient has been suffering from neuropathy is lesser, it will take lesser time for Cymbalta to work for neuropathy.

The other thing that matters when it comes to the timeframe for treatment efficacy of Cymbalta is the dosage that is being administered to the patient. If the dosage of Cymbalta is low, it takes time for the medicine to work. The progress is slower due to the low amount of Cymbalta being given to the patient.

Likewise, if the patient who is suffering from neuropathy is given a moderate dosage of Cymbalta, chances are that the medicine tends to work faster. It can even work in just about two to four weeks.

Another reason for Cymbalta taking time to work is the working of any medication. Any medicine when ingested starts working gradually, especially when it is taken for something serious as neuropathy.

Other factors that can lengthen the time for Cymbalta to work are the physical status of the patient including the age and the responsiveness to the medication.


The important thing that is to be noted with the use of Cymbalta for treating neuropathy is that it might show different results on different individuals. For some patients suffering from neuropathy, the result can come out faster. While for some patients, it can take even two months for substantial progress.

People with a pre-existing illness like liver or kidney issues might find that it takes longer for Cymbalta to work. Although the use of Cymbalta can lower down the symptoms of neuropathy, it tends to start other side effects like dry mouth or feeling sick, etc.


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