How Long After Klonopin Can I Take Ambien (And Why)?

Exact Answer:10-12 Hours

After a long day, you simply want to slump on your bed and have a restful sleep. Some people encounter this as soon as their head reaches the cushion. Others have trouble falling asleep.

Insomnia is unconsciousness in which you have complications in either falling or remaining dormant or both. Sleep medicine may appear to be a savior. And, when taken sparingly, it may help you get enough sleep.

AMBIEN is a sedative-hypnotic (sleep-inducing) medication. AMBIEN is prescribed to people for the short-term treatment of a sleep disorder known as insomnia (trouble falling asleep).

Whereas, Klonopin (clonazepam) is a medication used to treat panic attacks and seizure disorder. It is occasionally used off-label to medicate social nervousness derangement as SAD, (“Second-Line Medication”).

It is medically advised that the time difference between consuming both these drugs should be about 10-12 hours.

How Long After Klonopin Can I Take Ambien

How Long After Klonopin Can I Take Ambien?

Also known as Clonazepam works by suppressing the activity of nerve cells of the brain     Also known as zolpidem tartrate acts as a sedative-hypnotic medicine. 
Treats seizures, and panic disorders. Helps in reducing anxiety and stressTreats insomnia characterized by difficulties with sleep initiation

Benzodiazepine drugs, such as Klonopin (clonazepam), are used to treat anxiety, seizures, panic attacks, and insomnia by diffusing the stress response and slowing down specific central nervous system activities.

Whereas Ambien is also available in market as a branded version of zolpidem tartrate. Zolpidem is highly comparable to benzodiazepine tranquilizer such as valium, Ativan, Xanax, and Klonopin.

Such medicines can cause drowsiness and tranquility in one’s body by stimulating brain cells that links to GABA, a sleep-inducing chemical. Ambien and other hypnotic medications are prescribed by doctors to assist patients to fall asleep.

Nevertheless, these medications might have adverse side effects, particularly when combined with either each other or other medications.

When Klonopin is used with other hypnotic sedatives, such as Ambien, the sedative effects of each medication are essentially doubled.

Most of the patients prefer a combination of zolpidem or other sleep medicines with other drugs. Others fail to consider how their Ambien or other medical medicines may mix with Klonopin. Regardless of why you use other medications, combining substances is risky.

As a result, it is advisable to take Ambien after the effects of Klonopin have worn off through your body, which normally takes 10-12 hours.

Why Should I Keep a Time Difference of 10-12 Hours?

When Klonopin is used with Ambien, it may cause dizziness, sleepiness, disorientation, and difficulties concentrating. Some persons, particularly the elderly, may also develop cognitive, judgment, and motor coordination deficits.

A combination of both these medicines when taken together may result in unexpected outcomes. It can be complicated and critical for the patient’s nervous system. This might lead to unanticipated side effects or consequences.

Both drugs act as GABA—-Receptor agonists, opening chloride channels to neurons and effectively suppressing nerve activity. Benzodiazepines (Klonopin), barbiturates, alcohol, z-drugs (e.g., Ambien), some anesthetics (propofol and etomidate), and some seizure medications bind to this channel at different locations, resulting in different impacts on how the receptor operates.

Benzodiazepines, for example, bind to a ligand on the GABA-A receptor, causing the channel to open more often. Fortunately, benzodiazepines have a type of maximum impact on this binding site, so higher dosages will eventually fully saturate the receptor and the impact (increased frequency of channel opening) will max out. Alternatively, the barbiturate class connects to a different binding site and influences the duration of time the receptor remains open- making these medications more harmful since if a particular drug concentration is reached, the receptor will remain open and result in serious illness.

So, it is always advised to not mix these drugs, and to avoid mixing, an adequate amount of time gap is necessary!


Each medicine has the potential to enhance the sedative impact of the other. Combining chemicals can alter the activity of an active component. This can boost the effectiveness of that chemical on your body, reduce its effectiveness, or have other unanticipated consequences.

It was discovered that almost half of the individuals who seek emergency treatment as a result of zolpidem use had additional medications in their bodies. Among the drugs under question were prescription pain relievers, sleeping pills, and anti-anxiety medications.

When zolpidem is used with other medications, it decreases brain and nerve activity, your vital functions might be slowed to a dangerously slow rate. As a result, it is ordinarily suggested not to mix these medications, and to avoid mixing, a sufficient time interval is required! Ambien should be used after the effects of Klonopin have worn off in your body, which takes 10-12 hours.


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